Effect of Inhalation of Hydrogen Gas on Postoperative Recovery After Hepatectomy: A Randomized, Double-Blind, Placebo-Controlled Trial
H. Kosaka, Khanh Van Nguyen, K. Matsui, H. Matsushima, T. Miyauchi, G. Kiguchi, Hidekazu Yamamoto, Thanh Tung Lai, Hoang Hai Duong, Keita Mori, Hideki Ishikawa, Masaki Kaibori · Hydrogen · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In with elective hepatectomy were randomized (1:1) to receive 5% hydrogen gas or placebo air via nasal cannula from postoperativ, perioperative hydrogen inhalation significantly improved early postoperative recovery after hepatectomy, primarily through psychophysical domains of well-being. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in with elective hepatectomy were randomized (1:1) to receive 5% hydrogen gas or placebo air via nasal cannula from postoperativ. Perioperative hydrogen inhalation significantly improved early postoperative recovery after hepatectomy, primarily through psychophysical domains of well-being.
What the Researchers Studied
The researchers studied with elective hepatectomy were randomized (1:1) to receive 5% hydrogen gas or placebo air via nasal cannula from postoperativ. The study used a randomized, double-blind, placebo-controlled human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 5% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 5% source-reported H₂ gas concentration; via nasal cannula. Perioperative hydrogen inhalation significantly improved early postoperative recovery after hepatectomy, primarily through psychophysical domains of well-being. The authors concluded that hydrogen may selectively enhance emotional stability and functional independence during the early recovery phase. Hydrogen has antioxidant and anti-inflammatory properties that may attenuate perioperative stress responses.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, double-blind, placebo-controlled human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was with elective hepatectomy were randomized (1:1) to receive 5% hydrogen gas or placebo air via nasal cannula from postoperativ. The reported sample size was 8. The study used a randomized, double-blind, placebo-controlled human clinical trial. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 5% source-reported H₂ gas concentration.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://www.mdpi.com/2673-4141/6/4/124/pdf.