Effect of Treadmill Exercise and Hydrogen-rich Water Intake on Serum Oxidative and Anti-oxidative Metabolites in Serum of Thoroughbred Horses.
Hirokazu Tsubone, Masakazu Hanafusa, Maiko Endo, Noboru Manabe, Atsushi Hiraga, Hajime Ohmura, Hiroko Aida · Journal of equine science · 2013
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
The increase in d-ROMs tended to be lower in the HW trial, as compared to the placebo trial at pre-exercise. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water was evaluated in this publication and summarizes the source-grounded findings below. The increase in d-ROMs tended to be lower in the HW trial, as compared to the placebo trial at pre-exercise.
What the Researchers Studied
The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 1 mg/L H₂; Source-reported hydrogen exposure: 1 mg/L H₂; reported treatment duration: 33 days. The increase in d-ROMs tended to be lower in the HW trial, as compared to the placebo trial at pre-exercise. The authors concluded that these results demonstrate that the marked elevation of oxidative stress and anitioxidative functions occurred simultaneously in the intensively exercised horses, and suggest a possibility that HW has some antioxidative efficacy. In a rat model of sepsis, the intraperitoneal administration of hydrogen-rich water inhibited the increase of oxidative responses, such as ROS and malondialdehyde, in the hippocampus in a dose-dependent manner [ 43 ].
Why These Findings Matter
These findings add evidence supporting molecular hydrogen's therapeutic potential within the biological process and outcomes directly measured in this publication and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
H2HUBB classifies this publication as other research and interprets only the outcomes directly supported by the source record.
Technical Study Details
H2HUBB classifies this publication as other research with other supported evidence. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 1 mg/L H₂. The source-reported hydrogen exposure was 1 mg/L H₂. The reported treatment duration was 33 days.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://europepmc.org/article/PMC/PMC4013981.