Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study.
Atsunori Nakao, Yoshiya Toyoda, Prachi Sharma, Malkanthi Evans, Najla Guthrie · Journal of clinical biochemistry and nutrition · 2010
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 20 participants with potential metabolic syndrome, the effects of hydrogen rich water on the lipid profile in subjects who were current smokers demonstrated that there was a significant decrease in the total cholesterol/HDL ratio from baseline to week 4 (data not shown) and a significant increase in HDL from baseline to week 4 ( p <0.05). These findings add human evidence that helps define the outcomes that did and did not change with molecular hydrogen in this study.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in 20 participants with potential metabolic syndrome. The effects of hydrogen rich water on the lipid profile in subjects who were current smokers demonstrated that there was a significant decrease in the total cholesterol/HDL ratio from baseline to week 4 (data not shown) and a significant increase in HDL from baseline to week 4 ( p <0.05).
What the Researchers Studied
The researchers studied 20 participants with potential metabolic syndrome. The study used a human clinical study.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 0.55–0.65 mM H₂ (≈1.11–1.31 mg/L); Source-reported hydrogen exposure: 2 L hydrogen-rich water/day; dissolved H₂ concentration was not sufficiently reported, so H2HUBB did not estimate milligrams of H₂; H2HUBB calculated daily H₂ dose: approximately 2.22–2.62 mg H₂/day, calculated from the source-reported dissolved H₂ concentration and total hydrogen-water volume consumed per day. The effects of hydrogen rich water on the lipid profile in subjects who were current smokers demonstrated that there was a significant decrease in the total cholesterol/HDL ratio from baseline to week 4 (data not shown) and a significant increase in HDL from baseline to week 4 ( p <0.05). The effect of hydrogen rich water on markers of oxidative stress is presented in Table 2. In this study, the researchers demonstrated that drinking hydrogen rich water increased urinary anti-oxidant enzyme SOD, an endogenous defensive system against ROS-induced cellular injury, associated with reduction of oxidative stress markers, in subjects with metabolic syndrome [ 7 ]. the data demonstrated that subjects consuming hydrogen rich water for 8 weeks showed significantly increased SOD levels from baseline to week 8, suggesting that hydrogen rich water is capable of inducing SOD activity.
Why These Findings Matter
This publication adds useful evidence about where molecular hydrogen did and did not change the measured outcomes, helping define the larger therapeutic evidence base.
How Strong Is This Evidence?
This is human clinical evidence from a human clinical study. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 20 participants with potential metabolic syndrome. The reported sample size was 20. The study used a human clinical study. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 0.55–0.65 mM H₂ (≈1.11–1.31 mg/L). This is a deterministic dose translation, not a separately measured value.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.