Effects Of 12-Week Hydrogen-Rich Water Consumption on Body Composition and Metabolic Biomarkers in Adults with Metabolic Syndrome Stratified by Breath Hydrogen Levels: A Randomized Controlled Trial
Nikola Todorovic, David Nedeljkovic, Darinka Korovljev, Milos Obrenovic, Laszlo Ratgeber, Jozsef Betlehem, Viktoria Premusz, Pongrac Acs, Alex Tarnava, Sergej M. Ostojic · Current Topics in Nutraceutical Research · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
These findings add human evidence supporting molecular hydrogen's therapeutic potential for metabolic syndrome.
What the Findings Mean
Metabolic syndrome is a cluster of risk factors that increases the likelihood of cardiovascular disease and type 2 diabetes.
What the Researchers Studied
The study used a randomized, double-blind, placebo-controlled human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen exposure: 0 mL hydrogen-rich water/day; dissolved H₂ concentration was not sufficiently reported, so H2HUBB did not estimate milligrams of H₂. Metabolic syndrome is a cluster of risk factors that increases the likelihood of cardiovascular disease and type 2 diabetes.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential for metabolic syndrome and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, double-blind, placebo-controlled human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The reported sample size was 40. The study used a randomized, double-blind, placebo-controlled human clinical trial. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen exposure was 0 mL hydrogen-rich water/day; dissolved H₂ concentration was not sufficiently reported, so H2HUBB did not estimate milligrams of H₂.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://www.nchpjournals.com/journal/index.php/ctnr/article/view/29.