Effects of Hydrogen Gas Inhalation on Endometriosis in Rats.
Y He, J Z Shi, R J Zhang, D X Zhai, D Zhang, C Q Yu, Y H Liu · Reproductive sciences (Thousand Oaks, Calif.) · 2017
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In Sprague Dawley rats, both profiles of high-dose H₂ breathing reduced the size of the endometrial explants, inhibited cell proliferation, improved superoxide dismutase, glutathione peroxidase, malondialdehyde, and catalase activities, and regulated the expression of matrix metalloproteinase 9 and cyclooxygenase 2. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The aim of the present study is to evaluate the protective effect of H₂ on EMT in rats.
How Molecular Hydrogen Was Used
These results suggest that 67% H₂-33% O₂ breathing has a beneficial effect on EMT model rats, and inhalation of a high dose of H₂ could be a potential method applied in clinical practice.
What the Researchers Found
Both profiles of high-dose H₂ breathing reduced the size of the endometrial explants, inhibited cell proliferation, improved superoxide dismutase, glutathione peroxidase, malondialdehyde, and catalase activities, and regulated the expression of matrix metalloproteinase 9 and cyclooxygenase 2.
H₂ Mechanisms / Biological Findings
The source material reviewed did not establish a specific molecular hydrogen mechanism for the reported findings.
Authors’ Conclusion
The authors concluded that these results suggest that 67% H₂-33% O₂ breathing has a beneficial effect on EMT model rats, and inhalation of a high dose of H₂ could be a potential method applied in clinical practice.