Effects of hydrogen-rich water on depressive-like behavior in mice.
Yi Zhang, Wen-Jun Su, Ying Chen, Teng-Yun Wu, Hong Gong, Xiao-Liang Shen, Yun-Xia Wang, Xue-Jun Sun, Chun-Lei Jiang · Scientific reports · 2016
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Independent study record
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H2HUBB TAKEAWAY
In an animal model, cUMS induced elevation in IL-1β protein levels in the hippocampus, and the cortex was significantly attenuated after 4 weeks of feeding the mice hydrogen-rich water. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined preclinical animal experiment.
How Molecular Hydrogen Was Used
Molecular hydrogen was administered as hydrogen-rich water.
What the Researchers Found
CUMS induced elevation in IL-1β protein levels in the hippocampus, and the cortex was significantly attenuated after 4 weeks of feeding the mice hydrogen-rich water.
H₂ Mechanisms / Biological Findings
CUMS induced elevation in IL-1β protein levels in the hippocampus, and the cortex was significantly attenuated after 4 weeks of feeding the mice hydrogen-rich water. the data suggest that the beneficial effects of hydrogen-rich water on depressive-like behavior may be mediated by suppression of the inflammasome activation resulting in attenuated protein IL-1β and ROS production. Recent studies show that hydrogen selectively reduces cytotoxic oxygen radicals, and hydrogen-rich water potentially suppresses the production of several proinflammatory mediators. The researchers investigated the effects of drinking hydrogen-rich water on the depressive-like behavior in mice and its underlying mechanisms. the data suggest that the beneficial effects of hydrogen-rich water on depressive-like behavior may be mediated by suppression of the inflammasome activation resulting in attenuated protein IL-1β and ROS production.
Authors’ Conclusion
The authors concluded that the data suggest that the beneficial effects of hydrogen-rich water on depressive-like behavior may be mediated by suppression of the inflammasome activation resulting in attenuated protein IL-1β and ROS production.