Effects of long-term hydrogen intervention on the physiological function of rats.
Zhi-Ming Xun, Qing-Hui Zhao, Yan Zhang, Fang-di Ju, Jin He, Ting-Ting Yao, Xiao-Kang Zhang, Yang Yi, Sheng-Nan Ma, Peng-Xiang Zhao, Xiao-Yan Jin, Ying-Xian Li, Xiao-Yang Li, Xue-Mei Ma, Fei Xie · Scientific reports · 2020
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In the present study, the body weight and 13 serum biochemical parameters were monitored during the six-month hydrogen intervention, all these parameters were significantly altered by oral intake of HRW or HI. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how oxy-hydrogen gas inhalation affected the outcomes measured in rats. In the present study, the body weight and 13 serum biochemical parameters were monitored during the six-month hydrogen intervention, all these parameters were significantly altered by oral intake of HRW or HI.
What the Researchers Studied
The researchers studied rats. The study used a preclinical animal experiment. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 4% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 4% source-reported H₂ gas concentration. In the present study, the body weight and 13 serum biochemical parameters were monitored during the six-month hydrogen intervention, all these parameters were significantly altered by oral intake of HRW or HI. The authors concluded that alterations in most of the parameters, such as BW, UA, TG, ALT, AST, LDH, HDB, CK and CK-MB, were much more significant in HI than HRW, only the changes in TBA were more evident in HRW group. The results of this study provides the basic data for the mechanism research and application of molecular hydrogen in the future. The slow response to hydrogen may be mediated by the alterations of the gut microbiota, although the detailed mechanism needs to be further investigated.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was rats. The study used a preclinical animal experiment. The hydrogen delivery method was oxy-hydrogen gas inhalation. The source-reported hydrogen concentration was 4% source-reported H₂ gas concentration.
Limitations and Safety
Reported limitations: The limitation of the study may be the lack of monitoring of the food and water consumption, as well as defecation and urination in rats. Another limitation of this study is related to lack of measurement of the hydrogen concentration in the blood.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.