Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment.
Kiyomi Nishimaki, Takashi Asada, Ikuroh Ohsawa, Etsuko Nakajima, Chiaki Ikejima, Takashi Yokota, Naomi Kamimura, Shigeo Ohta · Current Alzheimer research · 2018
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Independent study record
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H2HUBB TAKEAWAY
In mice, drinking H₂-water decreased oxidative stress markers and suppressed the decline of memory impairment and neurodegeneration. In MCI participants, although there was no significant difference between the H₂- and control groups in ADAS-cog score after 1 year, carriers of the apolipoprotein E4 (APOE4) genotype in the H₂-group were improved significantly on total ADAS-cog score and word recall task score (one of the sub-scores in the ADAS-cog score).
What the Researchers Studied
The researchers previously reported that molecular hydrogen (H₂) acts as a therapeutic and preventive antioxidant.
How the Study Was Conducted
Randomized, double-blind, placebo-controlled human clinical trial.
How Molecular Hydrogen Was Used
Transgenic mice expressing a dominant-negative form of aldehyde dehydrogenase 2 were used as a dementia model.
What the Researchers Found
In mice, drinking H₂-water decreased oxidative stress markers and suppressed the decline of memory impairment and neurodegeneration. In MCI participants, although there was no significant difference between the H₂- and control groups in ADAS-cog score after 1 year, carriers of the apolipoprotein E4 (APOE4) genotype in the H₂-group were improved significantly on total ADAS-cog score and word recall task score (one of the sub-scores in the ADAS-cog score).