Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment.
Kiyomi Nishimaki, Takashi Asada, Ikuroh Ohsawa, Etsuko Nakajima, Chiaki Ikejima, Takashi Yokota, Naomi Kamimura, Shigeo Ohta · Current Alzheimer research · 2018
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In mice, drinking H₂-water decreased oxidative stress markers and suppressed the decline of memory impairment and neurodegeneration. In MCI participants, although there was no significant difference between the H₂- and control groups in ADAS-cog score after 1 year, carriers of the apolipoprotein E4 (APOE4) genotype in the H₂-group were improved significantly on total ADAS-cog score and word recall task score (one of the sub-scores in the ADAS-cog score). These findings add human evidence supporting molecular hydrogen's therapeutic potential for Alzheimer's disease.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in 73 participants with MCI. In mice, drinking H₂-water decreased oxidative stress markers and suppressed the decline of memory impairment and neurodegeneration. In MCI participants, although there was no significant difference between the H₂- and control groups in ADAS-cog score after 1 year, carriers of the apolipoprotein E4 (APOE4) genotype in the H₂-group were improved significantly on total ADAS-cog score and word recall task score (one of the sub-scores in the ADAS-cog score).
What the Researchers Studied
The researchers studied 73 participants with MCI. The study used a randomized, double-blind, placebo-controlled human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Transgenic mice expressing a dominant-negative form of aldehyde dehydrogenase 2 were used as a dementia model. In mice, drinking H₂-water decreased oxidative stress markers and suppressed the decline of memory impairment and neurodegeneration. In MCI participants, although there was no significant difference between the H₂- and control groups in ADAS-cog score after 1 year, carriers of the apolipoprotein E4 (APOE4) genotype in the H₂-group were improved significantly on total ADAS-cog score and word recall task score (one of the sub-scores in the ADAS-cog score). The authors concluded that H₂-water may have a potential for suppressing dementia in an oxidative stress model and in the APOE4 carriers with MCI.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential for Alzheimer's disease and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, double-blind, placebo-controlled human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 73 participants with MCI. The reported sample size was 73. The study used a randomized, double-blind, placebo-controlled human clinical trial.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.