Effects of pre-exercise H2 inhalation on physical fatigue and related prefrontal cortex activation during and after high-intensity exercise.
Yinglu Hong, Gengxin Dong, Qian Li, Vienna Wang, Meng Liu, Guole Jiang, Dapeng Bao, Junhong Zhou · Frontiers in physiology · 2022
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 24 young participants, it was observed that compared to control, after inhaling H₂ gas, participants had significantly lower RPE at each workload phase (p < 0.032) and lower HR at 50% Wmax, 75% Wmax, and 100% Wmax during cycling exercise (p < 0.037); the PFC activation was also significantly increased at 75 and 100% Wmax (p < 0.011).
What the Researchers Studied
In this study, the researchers examined the effects of pre-exercise H₂ gas inhalation on physical fatigue (PF) and prefrontal cortex (PFC) activation during and after high-intensity cycling exercise.
How the Study Was Conducted
Placebo-controlled human clinical trial.
How Molecular Hydrogen Was Used
On each of the other two visits, participants inhaled 20 min of either H₂ gas or placebo gas after a baseline test of maximal voluntary isometric contraction (MVIC) of thigh.
What the Researchers Found
It was observed that compared to control, after inhaling H₂ gas, participants had significantly lower RPE at each workload phase (p < 0.032) and lower HR at 50% Wmax, 75% Wmax, and 100% Wmax during cycling exercise (p < 0.037); the PFC activation was also significantly increased at 75 and 100% Wmax (p < 0.011).
Authors’ Conclusion
The authors concluded that this study demonstrated that pre-exercise inhalation of H₂ gas can alleviate PF, potentially by maintaining high PFC activation during high-intensity exercise in healthy young adults.