Experience with Photodynamic Therapy Using Indocyanine Green Liposomes for Refractory Cancer.
Kensho Yorozu, Masaki Kaibori, Shintarou Kimura, Misa Ichikawa, Kosuke Matsui, Soichiro Kaneshige, Masanori Kobayashi, Daiki Jimbo, Yusuke Torikai, Yoshitaka Fukuzawa, Yoshiharu Okamoto · Journal of personalized medicine · 2022
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
The researchers reported the development of an effective cancer treatment using a multidisciplinary treatment, including photodynamic therapy (PDT) with indocyanine green (ICG) liposomes and a combination of Lentinula edodes mycelia (LEM) and hydrogen gas inhalation therapy. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in Further, the patients received a combination of LEM and hydrogen gas inhalation therapy throughout the treatment. The researchers reported the development of an effective cancer treatment using a multidisciplinary treatment, including photodynamic therapy (PDT) with indocyanine green (ICG) liposomes and a combination of Lentinula edodes mycelia (LEM) and hydrogen gas inhalation therapy.
What the Researchers Studied
The researchers studied Further, the patients received a combination of LEM and hydrogen gas inhalation therapy throughout the treatment. The study used a human clinical study.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen exposure: 866 mL/min H₂ flow. The researchers reported the development of an effective cancer treatment using a multidisciplinary treatment, including photodynamic therapy (PDT) with indocyanine green (ICG) liposomes and a combination of Lentinula edodes mycelia (LEM) and hydrogen gas inhalation therapy. The authors concluded that in conclusion, the present findings suggest that the effect of PDT using ICG liposomes with LEM and hydrogen gas may eradicate cancer without burdening patients by enhancing tumor immunity. They suggested that hydrogen gas acts on the PD1/PDL1 pathway, allowing CTLs to efficiently attack cancer cells.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a human clinical study. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was Further, the patients received a combination of LEM and hydrogen gas inhalation therapy throughout the treatment. The study used a human clinical study. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen exposure was 866 mL/min H₂ flow.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.