Exploratory Evaluation of Hydrogen-Rich Water Therapy for Keloid Management: A Double-Blinded Randomized Pilot Trial.
Xinwen Kuang, Zhengyun Liang, Mengjie Shan, Yan Hao, Yijun Xia, Chao Xia, Hao Liu, Qiao Chen, Guojing Chang, Qianjun He, Youbin Wang · Aesthetic plastic surgery · 2026
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Independent study record
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H2HUBB TAKEAWAY
In 21 patients, anti-inflammatory cytokine IL-10 levels significantly increased after hydrogen-rich water therapy, while inflammation-related cytokines VEGF and TGF-β levels significantly decreased.
What the Researchers Studied
This research explores HRW's therapeutic potential and mechanism for keloid treatment.
How the Study Was Conducted
Randomized human clinical trial.
How Molecular Hydrogen Was Used
The HRW group received hydrogen in their drinking water, while the Con group drank hydrogen-free water.
What the Researchers Found
Anti-inflammatory cytokine IL-10 levels significantly increased after hydrogen-rich water therapy, while inflammation-related cytokines VEGF and TGF-β levels significantly decreased.
Authors’ Conclusion
The authors concluded that hydrogen-rich water therapy appears to be a safe and promising approach for symptom relief and inflammation modulation in keloid patients.