Gas as medicine: the case for hydrogen gas as a therapeutic agent for critical illness.
Lakhmir S Chawla · Intensive care medicine experimental · 2025
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
Molecular hydrogen gas (HG), administered through inhalation or as hydrogen-rich fluids (HRF), has demonstrated antioxidant, anti-inflammatory, antiapoptotic, cytoprotective, and beneficial mitochondrial effects in critical illness. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
How Molecular Hydrogen Was Addressed
Molecular hydrogen gas (HG), administered through inhalation or as hydrogen-rich fluids (HRF), has demonstrated antioxidant, anti-inflammatory, antiapoptotic, cytoprotective, and beneficial mitochondrial effects in critical illness. Given its accessibility, safety, and low-cost, hydrogen gas therapy should be assessed in adequately powered clinical trials in critical illness.
What the Publication Reported
Preclinical studies and human clinical studies consistently endorse hydrogen gas as safe, with mechanisms of action linked to vital molecular pathways, such as reductions in both oxidative stress and inflammation with beneficial effects on mitochondria.
H₂ Mechanisms / Biological Findings
Preclinical studies and human clinical studies consistently endorse hydrogen gas as safe, with mechanisms of action linked to vital molecular pathways, such as reductions in both oxidative stress and inflammation with beneficial effects on mitochondria. Molecular hydrogen gas (HG), administered through inhalation or as hydrogen-rich fluids (HRF), has demonstrated antioxidant, anti-inflammatory, antiapoptotic, cytoprotective, and beneficial mitochondrial effects in critical illness.