Health Effects of Electrolyzed Hydrogen Water for the Metabolic Syndrome and Pre-Metabolic Syndrome: A 3-Month Randomized Controlled Trial and Subsequent Analyses.
Reiko Moribe, Marina Minami, Ryoji Hirota, Naw Awn J-P, Shigeru Kabayama, Masamitsu Eitoku, Keiko Yamasaki, Hajime Kuroiwa, Narufumi Suganuma · Antioxidants (Basel, Switzerland) · 2024
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 181 participants with metabolic syndrome or pre-metabolic syndrome, although no significant difference was observed, several positive results were found in the participants who engaged in a high level of physical activity. These findings add human evidence that helps define the outcomes that did and did not change with molecular hydrogen in this study.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in 181 participants with metabolic syndrome or pre-metabolic syndrome. Although no significant difference was observed, several positive results were found in the participants who engaged in a high level of physical activity.
What the Researchers Studied
The researchers studied 181 participants with metabolic syndrome or pre-metabolic syndrome. The study used a randomized, double-blind, placebo-controlled human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Reported treatment duration: 3 months. Although no significant difference was observed, several positive results were found in the participants who engaged in a high level of physical activity. The authors concluded that based on the result, the researchers suggest that, among participants in the study who suffered from metabolic syndrome and pre-metabolic syndrome in which the level of active oxygen species is said to be higher than in healthy subjects, the group that consumed EHW and also engaged in a high level of physical activity experienced a suppressed or reduced increase in active oxygen species.
Why These Findings Matter
This publication adds useful evidence about where molecular hydrogen did and did not change the measured outcomes, helping define the larger therapeutic evidence base.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, double-blind, placebo-controlled human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 181 participants with metabolic syndrome or pre-metabolic syndrome. The reported sample size was 181. The study used a randomized, double-blind, placebo-controlled human clinical trial. The reported treatment duration was 3 months.
Limitations and Safety
Reported limitations: DISCUSSION: The difference between intervention and control groups among the high-physical-activity strata was significant enough to be detected even with the small sample size of the sub-group analysis.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.