Homeostatic and endocrine responses as the basis for systemic therapy with medical gases: ozone, xenon and molecular hydrogen.
Eugene Iv Nazarov, Igor Alb Khlusov, Mami Noda · Medical gas research · 2021
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. Repeated inhalation of mixed H₂ -O₂ gas [67%:33% (V/V)] significantly decreased both the acute and chronic stress-induced depressive and anxiety-like behaviors of mice, by blocking the stress-induced increase in the serum levels of corticosterone, adrenocorticotropic hormone, interleukin-6, and tumor necrosis factor-α. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. Repeated inhalation of mixed H₂ -O₂ gas [67%:33% (V/V)] significantly decreased both the acute and chronic stress-induced depressive and anxiety-like behaviors of mice, by blocking the stress-induced increase in the serum levels of corticosterone, adrenocorticotropic hormone, interleukin-6, and tumor necrosis factor-α.
What the Researchers Studied
The authors reviewed homeostatic and endocrine responses as the basis for systemic therapy with medical gases: ozone, xenon and molecular hydrogen.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 33% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 33% source-reported H₂ gas concentration. Repeated inhalation of mixed H₂ -O₂ gas [67%:33% (V/V)] significantly decreased both the acute and chronic stress-induced depressive and anxiety-like behaviors of mice, by blocking the stress-induced increase in the serum levels of corticosterone, adrenocorticotropic hormone, interleukin-6, and tumor necrosis factor-α. The authors concluded that upon analysis of published and proprietary data, the researchers concluded that these three medical gases can manipulate the neuroendocrine system, by modulating the production or release of hormones via the hypothalamic-pituitary-adrenal, hypothalamic-pituitary-thyroid, hypothalamic-pituitary-gonadal axes, or the gastrointestinal pathway. As for the role of unconditional reflex in hydrogen therapy, practically little is known so far, apart from the fact that the delayed anti-inflammatory effect of H₂ can be associated with the early local pro-inflammatory effect.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The study used a narrative review. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 33% source-reported H₂ gas concentration.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.