Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients With Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial.
Guohua Song, Quanqiang Lin, Hui Zhao, Meiyuan Liu, Fenglong Ye, Yujuan Sun, Yang Yu, Shoudong Guo, Peng Jiao, Yun Wu, Guoyong Ding, Qiang Xiao, Shucun Qin · The Journal of clinical endocrinology and metabolism · 2015
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In a laboratory model, H₂ treatment increased the effective rate in down-regulating plasma levels of total cholesterol (47.06% vs 17.65%) and LDL cholesterol (47.06% vs 23.53%). These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
PATIENTS: A total of 68 patients with untreated isolated hypercholesterolemia were randomly allocated to either drinking H₂-rich water (n = 34) or placebo water (n = 34) for 10 weeks.
How Molecular Hydrogen Was Used
CONTEXT: the researchers have found that hydrogen (dihydrogen [H₂]) decreases plasma low-density lipoprotein (LDL) cholesterol levels and improves high-density lipoprotein (HDL) function in patients with potential metabolic syndrome in a before-after self-controlled study.
What Molecular Hydrogen Changed
H₂ treatment increased the effective rate in down-regulating plasma levels of total cholesterol (47.06% vs 17.65%) and LDL cholesterol (47.06% vs 23.53%).
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.