Effects of inhalation of the hydrogen-rich gas before sleep on fatigue recovery in healthy adults
Li Q, Li Y, Liu H, Wang Y, Bao D, Liu H, Zhou J · 2024
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 100 healthy participants with no sleep disorders, no significant difference in the percent change of HRV paraments (i.e., LF/HF, RMSSD, SDNN, LF average, HF average, VLF average) and KSS scale from night to morning were observed between CS and HS ( p > 0.67). These findings add human evidence that helps define the outcomes that did and did not change with molecular hydrogen in this study.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in 100 healthy participants with no sleep disorders. No significant difference in the percent change of HRV paraments (i.e., LF/HF, RMSSD, SDNN, LF average, HF average, VLF average) and KSS scale from night to morning were observed between CS and HS ( p > 0.67).
What the Researchers Studied
The researchers studied 100 healthy participants with no sleep disorders. The study used a human clinical study. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen exposure: 1800 mL/min total gas flow; H₂ component not established; reported treatment duration: 20 minutes. No significant difference in the percent change of HRV paraments (i.e., LF/HF, RMSSD, SDNN, LF average, HF average, VLF average) and KSS scale from night to morning were observed between CS and HS ( p > 0.67). The authors concluded that the effect of inhalation of hydrogen oxygen mixture gas on sleep staging was not measured in this study due to the limitation of conditions, and it can also be accurately explored in the future by using polysomnography and so on.\u003c/p\u003e \u003c/div\u003e"},{"header":"Conclusions","content":"\u003cp\u003eInhaling hydrogen-rich gas before sleep can accelerate the recovery of muscle strength and muscle proprioception on the next day in healthy adults.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cem\u003eConflicts of interest\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eThe authors certify that there is no conflict of interest with any financial organization regarding the material discussed in the manuscript\u003c/p\u003e\n\u003cp\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003cem\u003eFunding\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eThis research was funded by a grant from National Key Research and Development Program of China (2019YFF0301803).\u003cs\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/s\u003e\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eAuthors\u0026rsquo; contributions\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eQian Li, Yiting Li, Haochong Liu, Yubo Wang, and Dapeng Bao have given substantial contributions to study conception and design, Qian Li, Yiting Li and Junhong Zhou to data acquisition, analysis and interpretation, Qian Li and Yiting Li to manuscript writing, Junhong Zhou, Haoyang Liu and Dapeng Bao to manuscript critical revision. Oxidative stress activates cGMP, which mediates NO regulation of normal sleep homeostasis.\u003csup\u003e\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e\u003c/sup\u003e Recent studies indicated that hydrogen down-modulates the activation of pro-inflammatory cytokines and NO.\u003csup\u003e\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e\u003c/sup\u003e Moreover, chronic sleep disruption may increase the activity of the sympathetic nervous system and lead to the disruption of the circadian clock.\u003csup\u003e\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e\u003c/sup\u003e Meanwhile, Mizuno et al. suggested lower sympathetic nerve activity (i.e., lower LF) after 4-week hydrogen water administration compared to the placebo water group.\u003csup\u003e\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e\u003c/sup\u003e the authors' insignificant results may arise from potential celling effects that the sleep quality in this group of healthy younger participants was good enough and cannot be further improved by intaking H\u003csub\u003e2\u003c/sub\u003e (e.g., the sleep duration were similar between CS and HS group). 11, 13, 14 Hydrogen can further activate Nrf2 pathways and subsequent induction of Phase-2 antioxidant enzymes to induce lasting effects on anti-oxidative stress for fatigue alleviation.
Why These Findings Matter
This publication adds useful evidence about where molecular hydrogen did and did not change the measured outcomes, helping define the larger therapeutic evidence base.
How Strong Is This Evidence?
This is human clinical evidence from a human clinical study. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 100 healthy participants with no sleep disorders. The reported sample size was 100. The study used a human clinical study. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen exposure was 1800 mL/min total gas flow; H₂ component not established. The reported treatment duration was 20 minutes.
Limitations and Safety
Reported limitations: Limitations the study focuses on the effects of a single inhalation of hydrogen oxygen mixture gas on fatigue recovery, and future studies could focus on long-term effects of intervention. Future studies implementing neuroimaging techniques are needed to explore and provide direct evidence to the effects of hydrogen on supraspinal control pertaining to fatigue and physical function in different populations (e.g., professional athlete who took long-term endurance training, or those non-athletic individuals).\u003c/p\u003e \u003cdiv id=\"Sec18\" class=\"Section2\"\u003e \u003ch2\u003eLimitations\u003c/H₂\u003e \u003cp\u003eOur study focuses on the effects of a single inhalation of hydrogen oxygen mixture gas on fatigue recovery, and future studies could focus on long-term effects of intervention.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://www.researchsquare.com/article/rs-4262540/v1.