Hydrogen attenuates endothelial glycocalyx damage associated with partial cardiopulmonary bypass in rats.
Hiroki Iwata, Takasumi Katoh, Sang Kien Truong, Tsunehisa Sato, Shingo Kawashima, Soichiro Mimuro, Yoshiki Nakajima · PloS one · 2023
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In male Sprague-Dawley rats, during partial CPB in rats, administration of 4% hydrogen via artificial and autologous lungs attenuated endothelial glycocalyx damage caused by CPB. These preclinical findings add evidence about the molecular-hydrogen effects, outcomes, and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in male Sprague-Dawley rats. During partial CPB in rats, administration of 4% hydrogen via artificial and autologous lungs attenuated endothelial glycocalyx damage caused by CPB.
What the Researchers Studied
The researchers studied male Sprague-Dawley rats. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Reported treatment duration: 60 minutes. During partial CPB in rats, administration of 4% hydrogen via artificial and autologous lungs attenuated endothelial glycocalyx damage caused by CPB. Hydrogen has anti-oxidant and anti-inflammatory properties; therefore, the researchers hypothesized that hydrogen would alleviate endothelial glycocalyx damage caused by CPB.
Why These Findings Matter
This publication adds useful evidence about where molecular hydrogen did and did not change the measured outcomes, helping define the larger therapeutic evidence base.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was male Sprague-Dawley rats. The reported sample size was 8. The study used a preclinical animal experiment. The reported treatment duration was 60 minutes.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.