Hydrogen-delivering biomaterial carriers for diabetic foot ulcer healing: a systematic review and meta-analysis of preclinical animal studies.
Xiaona Wang, Lei Pan, Haijun Shen · Diabetology & metabolic syndrome · 2026
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This meta analysis examined this study aimed to systematically evaluate the preclinical evidence on the therapeutic efficacy and underlying mechanisms of hydrogen-delivering biomaterial carriers in the treatment of diabetic foot ulcer (DFU). The analysis showed that the CD206 expression in the hydrogen-treated group had a statistically significant increase(SMD = 6.4, 95% CI: 1.91 to 10.89, P = 0.005). Continuous outcomes were pooled using the standardized mean difference (SMD) with 95% confidence intervals (CIs), given expected heterogeneity in measurement scales across studies. The I ² statistic was adopted for the quantification of between-study heterogeneity. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. The analysis showed that the CD206 expression in the hydrogen-treated group had a statistically significant increase(SMD = 6.4, 95% CI: 1.91 to 10.89, P = 0.005).
What the Researchers Studied
The authors reviewed this study aimed to systematically evaluate the preclinical evidence on the therapeutic efficacy and underlying mechanisms of hydrogen-delivering biomaterial carriers in the treatment of diabetic foot ulcer (DFU).
What Effects Did Molecular Hydrogen Have?
The analysis showed that the CD206 expression in the hydrogen-treated group had a statistically significant increase(SMD = 6.4, 95% CI: 1.91 to 10.89, P = 0.005). The authors concluded that future research should prioritize optimization of release kinetics, pharmacokinetic-pharmacodynamic modeling in diabetic wound beds, and exploration of synergistic combinations (e.g., with growth factors or antimicrobial agents) to advance toward clinically translatable, precision wound therapeutics.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (meta analysis).
Technical Study Details
H2HUBB classifies this publication as meta analysis with review or synthesis evidence. The study used a meta analysis.
Limitations and Safety
Reported limitations: Continuous outcomes were pooled using the standardized mean difference (SMD) with 95% confidence intervals (CIs), given expected heterogeneity in measurement scales across studies. The I ² statistic was adopted for the quantification of between-study heterogeneity. I ² ≤ 50%, which indicated low heterogeneity, promoted the adoption of a fixed-effects model; otherwise, a random-effects model was employed ( I ² > 50%).
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.