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Review or synthesisNarrative reviewOther or not reported

Hydrogen Gas: A Novel Type of Antioxidant in Modulating Sexual Organs Homeostasis.

Yaxing Zhang, Haimei Liu, Jinwen Xu, Shuhui Zheng, Lequan Zhou · Oxidative medicine and cellular longevity · 2021

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Independent study record

Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.

H2HUBB Research Library branded molecular hydrogen research image
Primary topic Molecular Hydrogen Overview
Evidence type Review or synthesis
Publication type Narrative review
Hydrogen method Other or not reported

H2HUBB TAKEAWAY

This narrative review examined the available molecular-hydrogen literature. The lightest and diffusible gas molecule hydrogen (H₂) has been shown to improve erectile dysfunction (ED), testis injuries, sperm motility in male, preserve ovarian function, protect against uterine inflammation, preeclampsia, and breast cancer in female. The reviewed evidence supports molecular hydrogen's therapeutic potential. Additional well-designed studies are needed to clarify clinical safety and effectiveness.

Main Findings Across the Literature

The lightest and diffusible gas molecule hydrogen (H₂) has been shown to improve erectile dysfunction (ED), testis injuries, sperm motility in male, preserve ovarian function, protect against uterine inflammation, preeclampsia, and breast cancer in female.

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Related Molecular Hydrogen Studies

Preclinical animal evidenceAnimal studyOther or not reported

Hydrogen gas inhalation alleviated cerebral ischemia/reperfusion injury by regulating mitophagy in SH-SY5Y cells and mice via PTEN-induced kinase 1/Parkin pathway.

Zhenkui Wang, Wei Feng, Jie Zhou, Lei Huang, Chuanfeng Fang, Jiarong Yuan, Hongsheng Chen, Li Xue · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2026

In SH-SY5Y cells, H₂ treatment significantly improved cell viability, attenuated oxidative stress and mitochondrial dysfunction, and enhanced mitophagy via activation of the PINK1/Parkin pathway. These results are preclinical and suggest molecular hydrogen's therapeutic potential…

Primary topic
Molecular Hydrogen Overview
Delivery method
Other or not reported
Study ID
DOI: 10.1016/j.jstrokecerebrovasdis.2026.108645
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Preclinical animal evidenceAnimal studyOther or not reported

[Role of Nrf2 in the protective effects of hydrogen against cerebral dysfunction in septic mice].

Lingling Liu, Keliang Xie, Hongguang Chen, Xiaoqing Dong, Guolin Wang, Yonghao Yu · Zhonghua wei zhong bing ji jiu yi xue · 2014

In mice, compared with the sham operation and hydrogen control groups, in the sepsis group, the number of normal pyramidal neurons in the hippocampal CA1 region was markedly reduced, the apoptotic index was marked…

Primary topic
Molecular Hydrogen Overview
Delivery method
Other or not reported
Main limitation
Preclinical animal findings may not translate directly to human outcomes. The intervention or follow-up…
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DOI: 10.3760/cma.j.issn.2095-4352.2014.09.005
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Preclinical animal evidenceAnimal studyhydrogen-rich water

[Alleviating effects of hydrogen on hyperhomocysteinemia and fatty liver induced by high-methionine diet].

Wen-Bin Chu, Tian-Qi Ding, Bo Wen, Jun-Yu Lu, Rong Fan, Xue-Wei Chen · Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology · 2022

Compared with the HMD group rats, the HMD+HRW group rats showed a significant decrease in Hcy in the blood, reduced liver damage, and increased Hcy metabolism key enzyme activity and mRNA expression in the…

Primary topic
Molecular Hydrogen Overview
Delivery method
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Main limitation
Preclinical animal findings may not translate directly to human outcomes.
Study ID
DOI: 10.12047/j.cjap.6382.2022.143
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