Hydrogen Gas Inhalation Attenuates Seawater Instillation-Induced Acute Lung Injury via the Nrf2 Pathway in Rabbits.
Mengyuan Diao, Sheng Zhang, Lifeng Wu, Le Huan, Fenglou Huang, Yunliang Cui, Zhaofen Lin · Inflammation · 2016
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In rabbits, hydrogen gas inhalation markedly improved lung endothelial permeability and decreased both MDA content and MPO activity in lung tissue; these changes were associated with decreases in TNF-α, IL-1β, and IL-6 in BALF. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined rabbits.
How Molecular Hydrogen Was Used
Although hydrogen gas inhalation is reportedly protective in multiple types of lung injury, the effect of hydrogen gas inhalation on seawater instillation-induced acute lung injury remains unknown. This study investigated the effect of hydrogen gas on seawater instillation-induced acute lung injury and explored the mechanisms involved. Rabbits were randomly assigned to control, hydrogen (2 % hydrogen gas inhalation), seawater (3 mL/kg seawater instillation), and seawater + hydrogen (3 mL/kg seawater instillation + 2 % hydrogen gas inhalation) groups.
What the Researchers Found
Hydrogen gas inhalation markedly improved lung endothelial permeability and decreased both MDA content and MPO activity in lung tissue; these changes were associated with decreases in TNF-α, IL-1β, and IL-6 in BALF.
H₂ Mechanisms / Biological Findings
This study investigated the effect of hydrogen gas on seawater instillation-induced acute lung injury and explored the mechanisms involved. These results demonstrate that hydrogen gas inhalation attenuates seawater instillation-induced acute lung injury in rabbits and that the protective effects observed may be related to the activation of the Nrf2 pathway.
Authors’ Conclusion
A distinct authors’ conclusion was not available in the source material reviewed by H2HUBB.