Hydrogen gas inhalation inhibits progression to the “irreversible” stage of shock after severe hemorrhage in rats.
Tadashi Matsuoka, Masaru Suzuki, Motoaki Sano, Kei Hayashida, Tomoyoshi Tamura, Koichiro Homma, Keiichi Fukuda, Junichi Sasaki · The journal of trauma and acute care surgery · 2017
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Independent study record
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H2HUBB TAKEAWAY
In rats, at 2 hours after fluid resuscitation, blood pressure remained in the normal range and metabolic acidosis was well compensated in the H₂ gas-treated rats, whereas the researchers observed decreased blood pressure and uncompensated metabolic acidosis and hyperkalemia in the surviving control gas-treated rats. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The researchers investigated whether hydrogen (H₂) gas inhalation would influence the tolerance to hemorrhagic shock and improve survival.
How Molecular Hydrogen Was Used
The rats were assigned to either the H₂ gas (1.3% H₂, 26% O₂, 72.7% N₂)-treated group or the control gas (26% O₂, 74% N₂)-treated group.
What the Researchers Found
At 2 hours after fluid resuscitation, blood pressure remained in the normal range and metabolic acidosis was well compensated in the H₂ gas-treated rats, whereas the researchers observed decreased blood pressure and uncompensated metabolic acidosis and hyperkalemia in the surviving control gas-treated rats.
Authors’ Conclusion
Clinically, H₂ gas inhalation is expected to stabilize the subject until curative treatment can be performed, thereby increasing the probability of survival after hemorrhagic shock. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.