Hydrogen gas inhalation protects against cutaneous ischaemia/reperfusion injury in a mouse model of pressure ulcer.
Wei Fang, Guizhen Wang, Luyan Tang, Huilin Su, Huyan Chen, Wanqing Liao, Jinhua Xu · Journal of cellular and molecular medicine · 2018
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Independent study record
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H2HUBB TAKEAWAY
In mice, H₂ remarkably decreased ROS accumulation and enhanced antioxidant enzymes activities by up-regulating expression of Nrf2 and its downstream components in wound tissue and/or H₂O₂ -treated endothelia. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined mice.
How Molecular Hydrogen Was Used
Molecular hydrogen (H₂ ) was reported to have protective effects on I/R injuries of various internal organs. In this study, the researchers investigated the effects of H₂ inhalation on pressure ulcer and the underlying mechanisms. H₂ inhalation significantly reduced wound area, 8-oxo-dG level (oxidative DNA damage) and cellular apoptosis rates in skin lesions.
What the Researchers Found
H₂ inhalation significantly reduced wound area, 8-oxo-dG level (oxidative DNA damage) and cellular apoptosis rates in skin lesions. H₂ remarkably decreased ROS accumulation and enhanced antioxidant enzymes activities by up-regulating expression of Nrf2 and its downstream components in wound tissue and/or H₂O₂ -treated endothelia. Meanwhile, H₂ inhibited the overexpression of MCP-1, E-selectin, P-selectin and ICAM-1 in oxidant-induced endothelia and reduced inflammatory cells infiltration and proinflammatory cytokines (TNF-α, IL-1, IL-6 and IL-8) production in the wound.
H₂ Mechanisms / Biological Findings
The therapeutic effects of molecular hydrogen might be related to its antioxidant, anti-inflammatory, pro-healing actions.
Authors’ Conclusion
The authors concluded that taken together, these data indicated that H₂ inhalation suppressed the formation of pressure ulcer in a mouse model.