Hydrogen Research Study
← Back to Research Library
Preclinical animal evidenceAnimal studyOther or not reported

Hydrogen gas inhalation therapy may not work sufficiently to mitigate oxidative stress induced with REBOA.

Yosuke Matsumura, Yosuke Hayashi, Makoto Aoki, Yoshimitsu Izawa · Scientific reports · 2024

Research-use notice

Independent study record

Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.

H2HUBB Research Library branded molecular hydrogen research image
Primary topic Gastrointestinal Health
Evidence type Preclinical animal evidence
Publication type Animal study
Hydrogen method Other or not reported

H2HUBB TAKEAWAY

In an animal model, hydrogen gas inhalation therapy exhibited no significant difference compared to the control group in survival, lactate level, 8-OHdG, and intestinal mucosal injury following REBOA in a hemorrhagic shock model. These preclinical findings add evidence about the molecular-hydrogen effects, outcomes, and biological pathways measured in this model.

What the Findings Mean

H2HUBB reviewed how molecular hydrogen was evaluated in this publication and summarizes the source-grounded findings below. Hydrogen gas inhalation therapy exhibited no significant difference compared to the control group in survival, lactate level, 8-OHdG, and intestinal mucosal injury following REBOA in a hemorrhagic shock model.

What the Researchers Studied

The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.

What Effects Did Molecular Hydrogen Have?

2% inhaled H₂ concentration. Hydrogen gas inhalation therapy exhibited no significant difference compared to the control group in survival, lactate level, 8-OHdG, and intestinal mucosal injury following REBOA in a hemorrhagic shock model.

Why These Findings Matter

This publication adds useful evidence about where molecular hydrogen did and did not change the measured outcomes, helping define the larger therapeutic evidence base.

How Strong Is This Evidence?

This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.

Technical Study Details

H2HUBB classifies this publication as animal study with preclinical animal evidence. The reported sample size was 10. The study used a preclinical animal experiment. The reported hydrogen concentration was 2% inhaled H₂ concentration.

Limitations and Safety

No separate limitations or safety findings were identified in the source text available to H2HUBB.

Original Study and H2HUBB Research Context

H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.