Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models.
Gerald A Matchett, Nancy Fathali, Yu Hasegawa, Vikram Jadhav, Robert P Ostrowski, Robert D Martin, Ihab R Dorotta, Xuejun Sun, John H Zhang · Brain research · 2009
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In moderate and severe neonatal HI models, hydrogen gas therapy (2.9% concentration H(2)) was not associated with decreased volume of infarction or decreased concentration of MDA. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
Sprague-Dawley rats
How Molecular Hydrogen Was Used
Hydrogen gas (H(2)) has been shown to ameliorate brain injury in experimental adult rat focal ischemia and in a mild neonatal hypoxia-ischemia (HI, 90 min hypoxia) rat model. In moderate and severe neonatal HI models, hydrogen gas therapy (2.9% concentration H(2)) was not associated with decreased volume of infarction or decreased concentration of MDA.
What the Researchers Found
In moderate and severe neonatal HI models, hydrogen gas therapy (2.9% concentration H(2)) was not associated with decreased volume of infarction or decreased concentration of MDA.
Authors’ Conclusion
These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.