Hydrogen Research Study
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Preclinical animal evidenceAnimal studyOther or not reported

Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models.

Gerald A Matchett, Nancy Fathali, Yu Hasegawa, Vikram Jadhav, Robert P Ostrowski, Robert D Martin, Ihab R Dorotta, Xuejun Sun, John H Zhang · Brain research · 2009

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Independent study record

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H2HUBB Research Library branded molecular hydrogen research image
Primary topic Molecular Hydrogen Overview
Evidence type Preclinical animal evidence
Publication type Animal study
Hydrogen method Other or not reported

H2HUBB TAKEAWAY

In moderate and severe neonatal HI models, hydrogen gas therapy (2.9% concentration H(2)) was not associated with decreased volume of infarction or decreased concentration of MDA. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.

What the Researchers Studied

Sprague-Dawley rats

How Molecular Hydrogen Was Used

Hydrogen gas (H(2)) has been shown to ameliorate brain injury in experimental adult rat focal ischemia and in a mild neonatal hypoxia-ischemia (HI, 90 min hypoxia) rat model. In moderate and severe neonatal HI models, hydrogen gas therapy (2.9% concentration H(2)) was not associated with decreased volume of infarction or decreased concentration of MDA.

What the Researchers Found

In moderate and severe neonatal HI models, hydrogen gas therapy (2.9% concentration H(2)) was not associated with decreased volume of infarction or decreased concentration of MDA.

Authors’ Conclusion

These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.