Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress.
Ching-Ying Wu, Wen-Li Hsu, Ming-Hsien Tsai, Jui-Lin Liang, Jian-He Lu, Chia-Jung Yen, Hsin-Su Yu, Mami Noda, Chi-Yu Lu, Chu-Huang Chen, Shian-Jang Yan, Tohru Yoshioka · Scientific reports · 2017
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In Decreased Ca2+ signaling is observed in aged cells, probably secondary to the formation of disulfide bonds among Ca2+ signaling-related proteins,, skin aging processes may involve ROS-induced protein dysfunction due to disulfide bond formation, and H₂ can protect oxidation of this process. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in Decreased Ca2+ signaling is observed in aged cells, probably secondary to the formation of disulfide bonds among Ca2+ signaling-related proteins., skin aging processes may involve ROS-induced protein dysfunction due to disulfide bond formation, and H₂ can protect oxidation of this process.
What the Researchers Studied
The researchers studied Decreased Ca2+ signaling is observed in aged cells, probably secondary to the formation of disulfide bonds among Ca2+ signaling-related proteins. The study used a in vitro cell-culture laboratory experiment.
What Effects Did Molecular Hydrogen Have?
Hydrogen peroxide (H₂O₂) elicits ROS that induces skin aging through oxidation of proteins, forming disulfide bridges with cysteine or methionine sulfhydryl groups. Molecular hydrogen (H₂) was found to be more effectively protected H₂O₂-induced IP3R1 dysfunction by reducing disulfide bonds, rather than quenching ROS. , skin aging processes may involve ROS-induced protein dysfunction due to disulfide bond formation, and H₂ can protect oxidation of this process., skin aging processes may involve ROS-induced protein dysfunction due to disulfide bond formation, and H₂ can protect oxidation of this process. The authors concluded that, skin aging processes may involve ROS-induced protein dysfunction due to disulfide bond formation, and H₂ can protect oxidation of this process.
Why These Findings Matter
These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
How Strong Is This Evidence?
This is laboratory evidence from a in vitro cell-culture laboratory experiment. It is most informative for the biological mechanisms, cellular responses, or biochemical outcomes directly measured.
Technical Study Details
H2HUBB classifies this publication as laboratory study with laboratory or cellular evidence. The research population or model was Decreased Ca2+ signaling is observed in aged cells, probably secondary to the formation of disulfide bonds among Ca2+ signaling-related proteins. The study used a in vitro cell-culture laboratory experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.