Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
Tomohiro Kawamura, Nobunao Wakabayashi, Norihisa Shigemura, Chien-Sheng Huang, Kosuke Masutani, Yugo Tanaka, Kentaro Noda, Ximei Peng, Toru Takahashi, Timothy R Billiar, Meinoshin Okumura, Yoshiya Toyoda, Thomas W Kensler, Atsunori Nakao · American journal of physiology. Lung cellular and molecular physiology · 2013
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Independent study record
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H2HUBB TAKEAWAY
In an animal model, hydrogen treatment during exposure to hyperoxia significantly improved blood oxygenation, reduced inflammatory events, and induced HO-1 expression. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
How Molecular Hydrogen Was Used
Inhaled hydrogen gas
What the Researchers Found
Hydrogen treatment during exposure to hyperoxia significantly improved blood oxygenation, reduced inflammatory events, and induced HO-1 expression.
Biological or Mechanistic Findings
Hydrogen treatment during exposure to hyperoxia significantly improved blood oxygenation, reduced inflammatory events, and induced HO-1 expression. The findings suggest a potentially novel and applicable solution to hyperoxic lung injury and provide new insight into the molecular mechanisms and actions of hydrogen. To determine whether hydrogen could reduce hyperoxic lung injury and investigate the underlying mechanisms, the researchers randomly assigned rats to four experimental groups and administered the following gas mixtures for 60 h: 98% oxygen (hyperoxia), 2% nitrogen; 98% oxygen (hyperoxia), 2% hydrogen; 98% balanced air (normoxia), 2% nitrogen; and 98% balanced air (normoxia), 2% hydrogen.
Authors’ Conclusion
The authors concluded that a potentially novel and applicable solution to hyperoxic lung injury and provide new insight into the molecular mechanisms and actions of hydrogen. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.