Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice.
Hiroshi Matsuura, Hisatake Matsumoto, Daisuke Okuzaki, Kentaro Shimizu, Hiroshi Ogura, Takeshi Ebihara, Tsunehiro Matsubara, Shin-Ichi Hirano, Takeshi Shimazu · The Journal of surgical research · 2021
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Independent study record
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H2HUBB TAKEAWAY
Seven-day survival rate in septic mice was significantly improved in the H₂ inhalation group compared with that in the control group. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined the researchers aimed to confirm effects of H₂ therapy on sepsis and reveal its therapeutic mechanism via RNA sequencing in multiple organs in septic mice.
How Molecular Hydrogen Was Used
Liver, intestine, and lungs in CLP mice receiving 24-h ± H₂ therapy were assessed by RNA sequencing.
What the Researchers Found
Seven-day survival rate in septic mice was significantly improved in the H₂ inhalation group compared with that in the control group (75% versus 40%, P < 0.05). H₂ treatment attenuated serum interleukin-6 and tumor necrosis factor-α levels at 24 h after CLP, and blood glucose levels were maintained in the H₂-treated group.
H₂ Mechanisms / Biological Findings
The source material reviewed did not establish a specific molecular hydrogen mechanism for the reported findings.
Authors’ Conclusion
The authors concluded that these findings may contribute to clarifying the mechanism of action of H₂ therapy in sepsis.