Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report.
Ji-Bing Chen, Zhong-Bao Pan, Duan-Ming Du, Wei Qian, Yang-Yang Ma, Feng Mu, Ke-Cheng Xu · World journal of clinical cases · 2019
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In CASE SUMMARY: The patient refused other treatments and began daily hydrogen inhalation therapy, three months after hydrogen therapy, the metastases in the abdominal cavity gradually reduced in size, her anemia and hypoalbuminemia were corrected, lymphocyte and tumor marker levels returned to normal, and the patient was able to resume normal life. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in CASE SUMMARY: The patient refused other treatments and began daily hydrogen inhalation therapy. Three months after hydrogen therapy, the metastases in the abdominal cavity gradually reduced in size, her anemia and hypoalbuminemia were corrected, lymphocyte and tumor marker levels returned to normal, and the patient was able to resume normal life.
What the Researchers Studied
The researchers studied CASE SUMMARY: The patient refused other treatments and began daily hydrogen inhalation therapy. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen exposure: 3 L/min total gas flow; H₂ component not established. Three months after hydrogen therapy, the metastases in the abdominal cavity gradually reduced in size, her anemia and hypoalbuminemia were corrected, lymphocyte and tumor marker levels returned to normal, and the patient was able to resume normal life. The authors concluded that this is the first report of an efficacy and safety study about hydrogen therapy in patient with metastatic GBC and a critical general condition, who has remained stable for more than 4 months. Hydrogen has been used to treat various states associated with oxidative stress, including trauma[ 21 ], neurodegenerative disease[ 22 ], inflammatory disease[ 23 ], metabolic syndrome[ 24 ], adverse reactions to chemotherapy[ 25 ], and radiation injury[ 26 ]. The proposed mechanism underlying the anti-cancer properties of hydrogen may involve: (1) Elimination of the high levels of ROS produced by cancer cells, thus inhibiting the proliferation, invasion, and migration of cancer cells[ 31 ]; (2) Downregulation of inflammatory factors, elimination of chronic inflammation, and modification of the microenvironment[ 32 ]; (3) Protection of mitochondria, which maintains energy generation and help correct hypoxia, thereby transforming the cardiovascular, endocrine, and nervous systems[ 11 ]; and (4) Restoration of the function of exhausted cytotoxic T cells, and enhancement of systemic anti-cancer effects[ 33 ].
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a case report. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as case report with human clinical evidence. The research population or model was CASE SUMMARY: The patient refused other treatments and began daily hydrogen inhalation therapy. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen exposure was 3 L/min total gas flow; H₂ component not established.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.