Hydrogen inhalation ameliorates ventilator-induced lung injury.
Chien-Sheng Huang, Tomohiro Kawamura, Sungsoo Lee, Naobumi Tochigi, Norihisa Shigemura, Bettina M Buchholz, John D Kloke, Timothy R Billiar, Yoshiya Toyoda, Atsunori Nakao · Critical care (London, England) · 2010
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In mice, inhaled hydrogen gas effectively reduced VILI-associated inflammatory responses, at both a local and systemic level, via its antioxidant, anti-inflammatory and antiapoptotic effects. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in mice. Inhaled hydrogen gas effectively reduced VILI-associated inflammatory responses, at both a local and systemic level, via its antioxidant, anti-inflammatory and antiapoptotic effects.
What the Researchers Studied
The researchers studied mice. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 2% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 2% source-reported H₂ gas concentration. Inhaled hydrogen gas effectively reduced VILI-associated inflammatory responses, at both a local and systemic level, via its antioxidant, anti-inflammatory and antiapoptotic effects. Hydrogen treatment significantly inhibited upregulation of the mRNAs for pro-inflammatory mediators and induced antiapoptotic genes.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was mice. The study used a preclinical animal experiment. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 2% source-reported H₂ gas concentration.
Limitations and Safety
Safety information: KEY MESSAGES: • Hydrogen inhalation therapy at a safe concentration mitigated ventilator-induced lung injury in mice. • Hydrogen inhalation demonstrated potent antioxidant and anti-inflammatory effects in a mouse ventilator-induced lung injury model. • Hydrogen reduced ventilation-induced epithelial apoptosis by induction of antiapoptotic genes. • Adjunctive therapy with inhaled therapeutic medical gas is promising and might be reasonable for lung disease as it would be an easily delivered and straightforward therapeutic option. • Hydrogen treatment of ventilated patients may potentially yield a novel, clinically feasible therapy that would be easy to incorporate without alteration of interventional and surgical procedures.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.