A Gallbladder Carcinoma Patient With Pseudo-Progressive Remission After Hydrogen Inhalation.
Jibing Chen, Feng Mu, Tianyu Lu, Yangyang Ma, Duanming Du, Kecheng Xu · OncoTargets and therapy · 2019
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Independent study record
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H2HUBB TAKEAWAY
In this case report, tumors initially enlarged and tumor markers rose after hydrogen inhalation, followed by continued remission resembling pseudo-progression after anti-PD-1 therapy.
What the Researchers Studied
The patient was able to resume normal life two and a half months after hydrogen inhalation and survived over 10 months.
How Molecular Hydrogen Was Used
Hydrogen therapy has been reported to convert exhausted programmed cell death receptor (PD-1)+CD8+ T cells to PD-1-CD8+ T cells, in advanced colorectal cancer patients, which is associated with significantly prolonged survival.
What the Researchers Found
Hydrogen therapy has been reported to convert exhausted programmed cell death receptor (PD-1)+CD8+ T cells to PD-1-CD8+ T cells, in advanced colorectal cancer patients, which is associated with significantly prolonged survival. The tumors were initially enlarged and displayed increased tumor marker expression following hydrogen inhalation therapy, after which they continued to remit, similar to the pseudo-progression that occurs after anti-PD-1 treatment.
H₂ Mechanisms / Biological Findings
Hydrogen therapy has been reported to convert exhausted programmed cell death receptor (PD-1)+CD8+ T cells to PD-1-CD8+ T cells, in advanced colorectal cancer patients, which is associated with significantly prolonged survival.
Authors’ Conclusion
The authors concluded that this is the first report of pseudo-progression followed by sustained remission after hydrogen inhalation. This phenomenon is similar to the pseudo-progression-remission pattern that occurs following PD-1 antibody treatment. These findings suggest that hydrogen may have an inhibitory effect on PD-1 expression.