Hydrogen: an advanced and safest gas option for cancer treatment.
Gupta N, Abd El-Gawaad NS, Mallasiy LO, Alghamdi S, Yadav VK · Medical gas research · 2025
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
This preclinical study evaluated hydrogen gas in an animal model. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined preclinical animal experiment.
How Molecular Hydrogen Was Used
Molecular hydrogen was administered as this study revealed that hydrogen gas inhalation 3 h/d can improve the prognosis and overall survival of stage iv colorectal carcinoma patients by decreasing the number of programmed cell death 1/cd8 + t cells.
What the Researchers Found
Additional Table 1 Potential anticancer properties of different gaseous molecules Gas Potential anticancer property Nitric oxide Increases nitrosation of mitochondria and DNA, and inhibits cellular respiration Carbon monoxide Apoptosis of tumor cells by enhancing reactive oxygen species Oxygen increases tumor oxygenation Hydrogen Scavenges reactive oxygen species and disrupts redox homeostasis Hydrogen sulfide Disarranges intracellular acidification, induces cell cycle arrest Sulfur dioxide Increases oxidative damage through reactive oxygen species production However, the reliability and implications of anticancer gas therapy are not fully understood.
H₂ Mechanisms / Biological Findings
Additional Table 1 Potential anticancer properties of different gaseous molecules Gas Potential anticancer property Nitric oxide Increases nitrosation of mitochondria and DNA, and inhibits cellular respiration Carbon monoxide Apoptosis of tumor cells by enhancing reactive oxygen species Oxygen increases tumor oxygenation Hydrogen Scavenges reactive oxygen species and disrupts redox homeostasis Hydrogen sulfide Disarranges intracellular acidification, induces cell cycle arrest Sulfur dioxide Increases oxidative damage through reactive oxygen species production However, the reliability and implications of anticancer gas therapy are not fully understood.
Authors’ Conclusion
The authors concluded that however, as an independent cancer treatment option, significant clinical work is suggested in this direction.