Fatigue disappearance in hemodialysis patients by dual approach with hydrogen gas inhalation and hydrogen-enriched dialysate: two case reports.
Ryoichi Nakazawa, Shintaro Nagami, Hiroshi Nozaki, Minako Yataka, Kazuhiro Akiyama, Takashi Uchino, Nakanobu Azuma · Medical gas research · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 4 patients, 6 This suggests that a higher concentration of H₂ is necessary to achieve further improvements in fatigue. These findings add human evidence supporting molecular hydrogen's therapeutic potential for stroke recovery.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in 4 patients. 6 This suggests that a higher concentration of H₂ is necessary to achieve further improvements in fatigue.
What the Researchers Studied
The researchers studied 4 patients.
What Effects Did Molecular Hydrogen Have?
2.5% inhaled H₂ concentration; 250 mL/min H₂ output; reported treatment duration: 45 months. 6 This suggests that a higher concentration of H₂ is necessary to achieve further improvements in fatigue. The authors concluded that 22 In conclusion, the results of this case study suggest that the authors' combined therapy can alleviate fatigue in patients undergoing HD. Molecular hydrogen (H₂ ) has antioxidant properties, which may help reduce oxidative stress by scavenging excess hydroxyl radicals, potentially improving well-being and alleviating fatigue.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential for stroke recovery and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a case report. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as case report with human clinical evidence. The research population or model was 4 patients. The reported sample size was 2. The hydrogen delivery method was inhaled hydrogen gas. The reported hydrogen concentration was 2.5% inhaled H₂ concentration. The reported treatment duration was 45 months.
Limitations and Safety
Reported limitations: 4, 5 Given the limitations of previous interventions and the multifactorial nature of fatigue in patients undergoing HD, innovative approaches to address the underlying causes of fatigue are crucial. As a limitation, the researchers report a case study involving a small number of patients.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://europepmc.org/article/PMC/PMC11515080.