Fatigue disappearance in hemodialysis patients by dual approach with hydrogen gas inhalation and hydrogen-enriched dialysate: two case reports.
Ryoichi Nakazawa, Shintaro Nagami, Hiroshi Nozaki, Minako Yataka, Kazuhiro Akiyama, Takashi Uchino, Nakanobu Azuma · Medical gas research · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 2 patients with fatigue, 6 This suggests that a higher concentration of H₂ is necessary to achieve further improvements in fatigue. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence fatigue-related outcomes.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in 2 patients with fatigue. 6 This suggests that a higher concentration of H₂ is necessary to achieve further improvements in fatigue.
What the Researchers Studied
The researchers studied 2 patients with fatigue.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 2.5% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 2.5% source-reported H₂ gas concentration; 250 mL/min H₂ flow; via nasal cannula; H2HUBB estimated inhaled H₂ concentration: approximately 0.8–1.1% under standard resting adult assumptions from the source-reported 0.25 L/min pure-H₂ flow; reported treatment duration: 3 months. 6 This suggests that a higher concentration of H₂ is necessary to achieve further improvements in fatigue. Molecular hydrogen (H₂ ) has antioxidant properties, which may help reduce oxidative stress by scavenging excess hydroxyl radicals, potentially improving well-being and alleviating fatigue.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence fatigue-related outcomes and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a case report. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as case report with human clinical evidence. The research population or model was 2 patients with fatigue. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 2.5% source-reported H₂ gas concentration. H2HUBB estimated inhaled H₂ concentration: approximately 0.8–1.1% under standard resting adult assumptions from the source-reported 0.25 L/min pure-H₂ flow. This is a calculated estimate, not a directly measured concentration, and actual inhaled H₂ varies with breathing pattern, ventilation, cannula capture, and gas losses. The reported treatment duration was 3 months.
Limitations and Safety
Reported limitations: As a limitation, the researchers report a case study involving a small number of patients.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.