Hydrogen inhalation improves mouse neurological outcomes after cerebral ischemia/reperfusion independent of anti-necroptosis.
Jun-Long Huang, Wen-Wu Liu, Xue-Jun Sun · Medical gas research · 2018
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In mice, hydrogen inhalation significantly reduced infarct volume, attenuated brain edema and improved neurobehavioral deficit in MCAO mice. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in mice. Hydrogen inhalation significantly reduced infarct volume, attenuated brain edema and improved neurobehavioral deficit in MCAO mice.
What the Researchers Studied
The researchers studied mice. The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 67% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 67% source-reported H₂ gas concentration; 0 mL/min total gas flow (approximately 0 mL/min H₂ component); reported treatment duration: 90 minutes. Hydrogen inhalation significantly reduced infarct volume, attenuated brain edema and improved neurobehavioral deficit in MCAO mice. Although the neuroprotective effects of hydrogen gas have been confirmed in some animal models and even in clinical trials, the concentration of hydrogen gas used is no higher than 4% due to safety concerns. The authors' group showed HCH inhalation could attenuate I/R injury in a rat model via inhibiting apoptosis, oxidative stress and inflammation, 15 and anti-autophagy is also involved in the neuroprotection of hydrogen gas (1.3%) in C57BL/6J mice with global cerebral ischemia.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was mice. The study used a preclinical animal experiment. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 67% source-reported H₂ gas concentration. The reported treatment duration was 90 minutes.
Limitations and Safety
Safety information: Although the neuroprotective effects of hydrogen gas have been confirmed in some animal models and even in clinical trials, the concentration of hydrogen gas used is no higher than 4% due to safety concerns.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.