Hydrogen inhalation is associated with a transient rightward shift in prefrontal oxyhemoglobin asymmetry and autonomic modulation.
Masamichi Moriya, Katsunori Oyama, Yutaka Den, Yukio Yamada, Kaoru Sakatani · Scientific reports · 2026
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This publication examined hydrogen gas using the study design reported by the authoritative source. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
What the Publication Examined
Hydrogen inhalation is associated with a transient rightward shift in prefrontal oxyhemoglobin asymmetry and autonomic modulation.
How Molecular Hydrogen Was Addressed
Molecular hydrogen (H₂) has selective antioxidant and anti-inflammatory properties, yet its immediate effects on human cerebral oxygenation and autonomic function remain unclear. In this study, the researchers evaluated acute central and autonomic responses to a single 30-minute session of hydrogen inhalation in healthy adults, using 99.9% hydrogen delivered via nasal cannula at a fixed flow rate of 300 mL/min. Cerebral oxygenation was assessed using time-domain near-infrared spectroscopy (TD-NIRS) to quantify the concentrations of oxyhemoglobin (oxy-Hb) and deoxyhemoglobin (deoxy-Hb) in the bilateral prefrontal cortex (PFC), and to calculate interhemispheric asymmetry indices before hydrogen inhalation, immediately after the end of inhalation, and at 30 and 90 min thereafter.
What the Publication Reported
Hydrogen inhalation is associated with a transient rightward shift in prefrontal oxyhemoglobin asymmetry and autonomic modulation.
H₂ Mechanisms / Biological Findings
Molecular hydrogen (H₂) has selective antioxidant and anti-inflammatory properties, yet its immediate effects on human cerebral oxygenation and autonomic function remain unclear.
Authors’ Conclusion
A distinct authors’ conclusion was not available in the source material reviewed by H2HUBB.