Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and resuscitation.
Keisuke Kohama, Hayato Yamashita, Michiko Aoyama-Ishikawa, Toru Takahashi, Timothy R Billiar, Takeshi Nishimura, Joji Kotani, Atsunori Nakao · Surgery · 2015
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In rats, exposure to 1.3% hydrogen significantly attenuated the upregulation of the messenger RNAs for several proinflammatory mediators induced by HS/R. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
Rats
How Molecular Hydrogen Was Used
After HS/R, the rats were maintained in a control gas of similar composition to room air or exposed to 1.3% hydrogen.
What the Researchers Found
Exposure to 1.3% hydrogen significantly attenuated the upregulation of the messenger RNAs for several proinflammatory mediators induced by HS/R.
Biological or Mechanistic Findings
Exposure to 1.3% hydrogen significantly attenuated the upregulation of the messenger RNAs for several proinflammatory mediators induced by HS/R. Hydrogen, administered through inhalation, may exert potent therapeutic effects against ALI induced by HS/R and attenuate the activation of inflammatory cascades. Hydrogen, a therapeutic gas, has potent cytoprotective, antiinflammatory, and antioxidant effects.
Authors’ Conclusion
The authors concluded that hydrogen, administered through inhalation, may exert potent therapeutic effects against ALI induced by HS/R and attenuate the activation of inflammatory cascades. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.