Postconditioning with inhaled hydrogen attenuates skin ischemia/reperfusion injury through the RIP-MLKL-PGAM5/Drp1 necrotic pathway.
Xin-Hang Dong, Hao Liu, Ming-Zi Zhang, Peng-Xiang Zhao, Shu Liu, Yan Hao, You-Bin Wang · American journal of translational research · 2019
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Independent study record
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H2HUBB TAKEAWAY
In male Sprague-Dawley rats, rIP1, RIP3, MLKL, PGAM5 and Drp1 were expressed at high levels in the IR group, and their expression was significantly decreased in the hydrogen treatment group. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined male Sprague-Dawley rats.
How Molecular Hydrogen Was Used
After undergoing 3 h of I/R management, the surgery groups were treated with ambient air (SH and IR) and high concentrations of hydrogen (HCH).
What the Researchers Found
RIP1, RIP3, MLKL, PGAM5 and Drp1 were expressed at high levels in the IR group, and their expression was significantly decreased in the HCH group.
H₂ Mechanisms / Biological Findings
Reported molecular-hydrogen-related mechanisms included this study explored the flap-protective effects of high concentrations of hydrogen (HCH) inhalation in a rat flap ischemia/reperfusion (I/R) injury model and the potential mechanism of necroptosis.
Authors’ Conclusion
A distinct authors’ conclusion was not available in the source material reviewed by H2HUBB.