Hydrogen inhibits the proliferation and migration of gastric cancer cells by modulating lncRNA MALAT1/miR-124-3p/EZH2 axis.
Baocheng Zhu, Hengguan Cui, Weiqiang Xu · Cancer cell international · 2021
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In Gastric cancer cell lines MGC-803 and BGC-823 were treated with or without H₂ /O₂ gas mixture (66.7%:33.3% v/v), H₂ gas significantly inhibited gastric tumor growth in vivo and the proliferation, migration, and lncRNA MALAT1 and EZH2 expression of gastric cancer cells while upregulated miR-124-3p expression. The authors concluded that these data demonstrated that H₂ might be developed as a therapeutics of gastric cancer and lncRNA MALAT1/miR-124-3p/EZH2 axis could be a target for intervention. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in Gastric cancer cell lines MGC-803 and BGC-823 were treated with or without H₂ /O₂ gas mixture (66.7%:33.3% v/v). H₂ gas significantly inhibited gastric tumor growth in vivo and the proliferation, migration, and lncRNA MALAT1 and EZH2 expression of gastric cancer cells while upregulated miR-124-3p expression.
What the Researchers Studied
The researchers studied Gastric cancer cell lines MGC-803 and BGC-823 were treated with or without H₂ /O₂ gas mixture (66.7%:33.3% v/v). The study used a in vitro cell-culture laboratory experiment.
What Effects Did Molecular Hydrogen Have?
Gastric cancer cell lines MGC-803 and BGC-823 were treated with or without H₂ /O₂ gas mixture (66.7%:33.3% v/v). H₂ gas significantly inhibited gastric tumor growth in vivo and the proliferation, migration, and lncRNA MALAT1 and EZH2 expression of gastric cancer cells while upregulated miR-124-3p expression. The authors concluded that these data demonstrated that H₂ might be developed as a therapeutics of gastric cancer and lncRNA MALAT1/miR-124-3p/EZH2 axis could be a target for intervention.
Why These Findings Matter
These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
How Strong Is This Evidence?
This is laboratory evidence from a in vitro cell-culture laboratory experiment. It is most informative for the biological mechanisms, cellular responses, or biochemical outcomes directly measured.
Technical Study Details
H2HUBB classifies this publication as laboratory study with laboratory or cellular evidence. The research population or model was Gastric cancer cell lines MGC-803 and BGC-823 were treated with or without H₂ /O₂ gas mixture (66.7%:33.3% v/v). The study used a in vitro cell-culture laboratory experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.