Hydrogen inhibits the proliferation and migration of gastric cancer cells by modulating lncRNA MALAT1/miR-124-3p/EZH2 axis.
Baocheng Zhu, Hengguan Cui, Weiqiang Xu · Cancer cell international · 2021
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In Gastric cancer cell lines MGC-803 and BGC-823 were treated with or without H₂ /O₂ gas mixture (66.7%:33.3% v/v), H₂ gas significantly inhibited gastric tumor growth in vivo and the proliferation, migration, and lncRNA MALAT1 and EZH2 expression of gastric cancer cells while upregulated miR-124-3p expression. The authors concluded that these data demonstrated that H₂ might be developed as a therapeutics of gastric cancer and lncRNA MALAT1/miR-124-3p/EZH2 axis could be a target for intervention. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
This study aimed to investigate the effect of hydrogen gas on the behavior of gastric cancer cells.
Laboratory Model
Gastric cancer cell lines MGC-803 and BGC-823 were treated with or without H₂ /O₂ gas mixture (66.7%:33.3% v/v).
How Molecular Hydrogen Was Used
Gastric cancer cell lines MGC-803 and BGC-823 were treated with or without H₂ /O₂ gas mixture (66.7%:33.3% v/v).
What Molecular Hydrogen Changed
H₂ gas significantly inhibited gastric tumor growth in vivo and the proliferation, migration, and lncRNA MALAT1 and EZH2 expression of gastric cancer cells while upregulated miR-124-3p expression.
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.