Synergistic effect of hyperbaric oxygen preconditioning and hydrogen-rich saline in ameliorating rat flap ischemia/reperfusion injury
Yi-Ding Xiao, Yun-Qi Liu, Ming-Zi Zhang, You-Bin Wang, Yi-Fang Liu, Xue-Mei Ma · Plastic and Aesthetic Research · 2015
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In male Sprague-Dawley rats, both HBO and HRS treatments increase the rate of flap survival, while the synergistic application of HBO and HRS showed a higher survival rate as compared to individual treatments of each. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in male Sprague-Dawley rats. Both HBO and HRS treatments increase the rate of flap survival, while the synergistic application of HBO and HRS showed a higher survival rate as compared to individual treatments of each.
What the Researchers Studied
The researchers studied male Sprague-Dawley rats. The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
Reported treatment duration: 60 min. Both HBO and HRS treatments increase the rate of flap survival, while the synergistic application of HBO and HRS showed a higher survival rate as compared to individual treatments of each.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was male Sprague-Dawley rats. The study used a preclinical animal experiment. The hydrogen delivery method was inhaled hydrogen gas. The reported treatment duration was 60 min.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.