Hydrogen-Mediated Activation of the Nrf2/HO-1 Signaling Pathway Improves Cognitive Impairment in Sleep-Deprived Mice.
QiFan Xiao, ShiRui Zhou, Bin Tang, YuQing Zhu · CNS neuroscience & therapeutics · 2026
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
The results demonstrated that H₂-treated mice showed significantly shorter escape latency, longer target quadrant duration, and higher NOR index compared to controls. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in female C57BL/6 mice. The results demonstrated that H₂-treated mice showed significantly shorter escape latency, longer target quadrant duration, and higher NOR index compared to controls.
What the Researchers Studied
The researchers studied female C57BL/6 mice. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 66.7% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 66.7% source-reported H₂ gas concentration; reported treatment duration: 7 days. The results demonstrated that H₂-treated mice showed significantly shorter escape latency, longer target quadrant duration, and higher NOR index compared to controls. The authors concluded that these results indicate that H₂ alleviates oxidative stress and neuroinflammation through Nrf2/HO-1 pathway activation, mitigating SD-induced cognitive impairment. This study investigated the effects of hydrogen (H₂) on cognitive impairment in sleep-deprived mice mediated by the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was female C57BL/6 mice. The study used a preclinical animal experiment. The source-reported hydrogen concentration was 66.7% source-reported H₂ gas concentration. The reported treatment duration was 7 days.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.