Hydrogen Molecule Delivery System to Ischemic Intestine Using Resuscitative Endovascular Balloon Occlusion of Aorta in Hemorrhagic Shock—A Proof-of-Concept Study
Takahiro Yamanaka, Tadashi Matsuoka, Koichiro Homma, Tomoyoshi Tamura, Sayuri Suzuki, Shohei Suzuki, Daiki Kaito, Jo Yoshizawa, Keitaro Yajima, Soichiro Ono, Katsuya Maeshima, Eiji Kobayashi, Motoaki Sano, Junichi Sasaki · Biomedicines · 2026
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In an animal model, increased hydrogen concentration in the portal vein indicated that hydrogen was delivered to the intestine. These preclinical findings add evidence about the molecular-hydrogen effects, outcomes, and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen was evaluated in this publication and summarizes the source-grounded findings below. Increased hydrogen concentration in the portal vein indicated that hydrogen was delivered to the intestine.
What the Researchers Studied
The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
The top tip of the catheter was positioned distal to the REBOA balloon, and H₂ -containing saline was administered through the lumen of the catheter ( Figure 1 ). The H₂ transfer device was assembled immediately before use, and H₂ was injected into normal saline from the H₂ -absorbing alloy canister through a pressure regulator valve ( Figure 2 ). Increased hydrogen concentration in the portal vein indicated that hydrogen was delivered to the intestine.
Why These Findings Matter
This publication adds useful evidence about where molecular hydrogen did and did not change the measured outcomes, helping define the larger therapeutic evidence base.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The reported sample size was 4. The study used a preclinical animal experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.