Hydrogen molecules (H2) improve perfusion recovery via antioxidant effects in experimental peripheral arterial disease.
Jinrong Fu, Jinjing Zou, Cheng Chen, Hongying Li, Lei Wang, Yanli Zhou · Molecular medicine reports · 2018
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Independent study record
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H2HUBB TAKEAWAY
In a laboratory model, laser Doppler perfusion imaging demonstrated that H₂‐saturated water improved perfusion recovery, decreased the rate of necrosis, increased the capillary density in the gastrocnemius muscle and increased the artery density in the abductor muscle in the ischemic limbs, at 14 and 21 days post‐hindlimb ischemia. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen was evaluated in this publication and summarizes the source-grounded findings below. Laser Doppler perfusion imaging demonstrated that H₂‐saturated water improved perfusion recovery, decreased the rate of necrosis, increased the capillary density in the gastrocnemius muscle and increased the artery density in the abductor muscle in the ischemic limbs, at 14 and 21 days post‐hindlimb ischemia.
What the Researchers Studied
The study used a laboratory experiment.
What Effects Did Molecular Hydrogen Have?
Laser Doppler perfusion imaging demonstrated that H₂‐saturated water improved perfusion recovery, decreased the rate of necrosis, increased the capillary density in the gastrocnemius muscle and increased the artery density in the abductor muscle in the ischemic limbs, at 14 and 21 days post‐hindlimb ischemia.
Why These Findings Matter
These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
How Strong Is This Evidence?
This is laboratory evidence from a laboratory experiment. It is most informative for the biological mechanisms, cellular responses, or biochemical outcomes directly measured.
Technical Study Details
H2HUBB classifies this publication as laboratory study with laboratory or cellular evidence. The study used a laboratory experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.