Hydrogen-oxygen therapy can alleviate radiotherapy-induced hearing loss in patients with nasopharyngeal cancer.
Jibing Chen, Xiaofeng Kong, Feng Mu, Tianyu Lu, Duanming Du, Kecheng Xu · Annals of palliative medicine · 2019
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 3 patients with nasopharyngeal carcinoma developed binaural secretory otitis media 12, after 0.5, 1 and 2 months of continuous hydrogen-oxygen therapy, the authors' first three patients reported different levels of improvement in binaural hearing. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in 3 patients with nasopharyngeal carcinoma developed binaural secretory otitis media 12. After 0.5, 1 and 2 months of continuous hydrogen-oxygen therapy, the authors' first three patients reported different levels of improvement in binaural hearing.
What the Researchers Studied
The researchers studied 3 patients with nasopharyngeal carcinoma developed binaural secretory otitis media 12.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 67% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 67% source-reported H₂ gas concentration; 3 L/min H₂ flow (3000 mL/min H₂). After 0.5, 1 and 2 months of continuous hydrogen-oxygen therapy, the authors' first three patients reported different levels of improvement in binaural hearing. In the authors' three patients, after HOT, the pus in the ear disappeared, and the threshold of air conduction and bone conduction decreased considerably, which may have been related to the anti-oxidation and anti-inflammatory effects of the hydrogen–oxygen mixture. treatment with a mixture of hydrogen and oxygen can improve local hypoxia, reduce inflammation, reduce oxidative stress, and aid cell repair.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a case report. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as case report with human clinical evidence. The research population or model was 3 patients with nasopharyngeal carcinoma developed binaural secretory otitis media 12. The reported sample size was 3. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 67% source-reported H₂ gas concentration.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://apm.amegroups.org/article/view/32168/26860.