Hydrogen-Rich Saline Activated Autophagy via HIF-1α Pathways in Neuropathic Pain Model.
Huixing Wang, Xiaodong Huo, Hongguang Chen, Bo Li, Jingzhi Liu, Wenting Ma, Xiaojuan Wang, Keliang Xie, Yonghao Yu, Kemei Shi · BioMed research international · 2018
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Independent study record
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H2HUBB TAKEAWAY
In Sprague-Dawley rats, hRS improved MWT and TWL, activated autophagy, and increased autophagosomes and autolysosomes in CCI rats. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
Hydrogen-rich saline (HRS) reportedly reduces allodynia and hyperalgesia in a neuropathic pain model; however, it is unknown whether these effects involve autophagy induction.
What the Researchers Found
HRS improved MWT and TWL, activated autophagy, and increased autophagosomes and autolysosomes in CCI rats.
Authors’ Conclusion
The authors concluded that hRS reduced mechanical hyperalgesia and activation of cell autophagy in neuropathic pain through a HIF1-dependent pathway. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.