Hydrogen-Rich Saline Attenuates Acute Kidney Injury After Liver Transplantation via Activating p53-Mediated Autophagy.
Hongyin Du, Mingwei Sheng, Li Wu, Yamin Zhang, Dongjing Shi, Yiqi Weng, Rubin Xu, Wenli Yu · Transplantation · 2016
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Independent study record
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H2HUBB TAKEAWAY
In Adult male Sprague-Dawley rats were randomly allocated into four groups: sham, OLT, OLT with HRS (6 ml/kg) pretreatment (HS), OLT with HRS and chloroquine pretreatment (60 mg/kg) group (CQ), compared with the OLT group, HRS dramatically attenuated the histopathologic damage, restored the renal function, and decreased the oxidative stress level.
What the Researchers Studied
The present study aimed to explore the role of p53-mediated autophagy in the protective effect of hydrogen-rich saline (HRS) on AKI after orthotropic liver transplantation (OLT).
How the Study Was Conducted
Randomized human clinical trial.
What the Researchers Found
Compared with the OLT group, HRS dramatically attenuated the histopathologic damage, restored the renal function, and decreased the oxidative stress level.
Authors’ Conclusion
The authors concluded that hRS is able to protect against AKI after liver transplantation partly by reducing apoptosis, which is possibly involved in the modulation of p53-mediated autophagy.