Hydrogen-rich saline attenuates chemotherapy-induced ovarian injury via regulation of oxidative stress.
Xiaoyin Meng, Hongguang Chen, Guolin Wang, Yonghao Yu, Keliang Xie · Experimental and therapeutic medicine · 2015
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Independent study record
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H2HUBB TAKEAWAY
In The aim of the present study was to investigate whether hydrogen-rich saline treatment could attenuate ovarian damage induced by cisplatin, hydrogen-rich saline attenuated the FSH release, elevated the level of E2, improved the development of follicles, and reduced the damage to the ovarian cortex at T1, T2 and T3 in the OI + H₂ rats.
What the Researchers Studied
The aim of the present study was to investigate whether hydrogen-rich saline treatment could attenuate ovarian damage induced by cisplatin.
How the Study Was Conducted
Randomized human clinical trial.
How Molecular Hydrogen Was Used
In the OI and OI + H₂ groups, the rats were administered a dose of cisplatin on the 1st and 7th days. The rats in the Con + H₂ and OI + H₂ groups were intraperitoneally injected with hydrogen-rich saline (10ml/kg body weight) once a day over a 2-week period.
What the Researchers Found
Hydrogen-rich saline attenuated the FSH release, elevated the level of E2, improved the development of follicles, and reduced the damage to the ovarian cortex at T1, T2 and T3 in the OI + H₂ rats.
Authors’ Conclusion
The authors concluded that in conclusion, hydrogen-rich saline exerts a protective effect against cisplatin-induced ovarian injury by reducing MDA and increasing SOD and CAT activity.