Hydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats.
Yanqing Feng, Ruobing Wang, Jiajun Xu, Jingchuan Sun, Tao Xu, Qing Gu, Xingwei Wu · Current eye research · 2013
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Independent study record
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H2HUBB TAKEAWAY
In male Sprague-Dawley rats, sTZ-diabetic rats were marked by clearly reduced b-wave amplitudes and oscillatory potentials, DM-related BRB breakdown and histological changes in the inner retina, all of which were suppressed following treatment with hydrogen-rich saline. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined in the present study, the researchers assessed the effects of hydrogen-rich saline on neurovascular dysfunction and oxidative stress in an animal model (rat) of DR.
How Molecular Hydrogen Was Used
Male Sprague-Dawley rats with streptozotocin (STZ)-induced diabetes mellitus (DM) were injected intraperitoneally with 5 ml/kg hydrogen-saturated (experimental) or plain (control) saline daily for one month.
What the Researchers Found
STZ-diabetic rats were marked by clearly reduced b-wave amplitudes and oscillatory potentials, DM-related BRB breakdown and histological changes in the inner retina, all of which were suppressed following treatment with hydrogen-rich saline. reduced oxidative stress, increased antioxidant enzyme activities and preserved synaptophysin and BDNF levels in the diabetic rat retina.
H₂ Mechanisms / Biological Findings
Hydrogen-rich saline reduced oxidative stress, increased antioxidant enzyme activities and preserved synaptophysin and BDNF levels in the diabetic rat retina. Based on its inhibition of oxidative stress and up-regulation of anti-oxidative enzymes, the authors concluded that hydrogen-rich saline is a potentially valuable therapeutic modality for the treatment of DR. Previous studies on a variety of organs indicate that hydrogen-rich saline not only has considerable antioxidant and anti-inflammatory properties, but also suppresses oxidative stress-induced injury.
Authors’ Conclusion
The authors concluded that based on its inhibition of oxidative stress and up-regulation of anti-oxidative enzymes, the authors concluded that hydrogen-rich saline is a potentially valuable therapeutic modality for the treatment of DR.