Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model.
Min Fan, Xianlin Xu, Xiaozhou He, Lujun Chen, Liren Qian, Jipu Liu, Jiandi Qing, Zhifu Chao, Xuejun Sun · The Journal of urology · 2013
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H2HUBB TAKEAWAY
In rats, maximum intracavernous pressure in diabetic rats decreased significantly compared to controls and increased significantly compared to untreated diabetic rats after hydrogen-rich saline treatment. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The researchers investigated the effect of hydrogen on erectile dysfunction in streptozotocin induced diabetic rats.
How Molecular Hydrogen Was Used
Diabetic rats were then randomized to a diabetes mellitus group and to a diabetic group that received hydrogen saline.
What the Researchers Found
Maximum intracavernous pressure in diabetic rats decreased significantly compared to controls and increased significantly compared to untreated diabetic rats after hydrogen-rich saline treatment. Hydrogen-rich saline improved nitric oxide synthase activity, and malondialdehyde, nitrite and nitrate, and 8-hydroxydeoxyguanosine levels in the diabetic rat corpus cavernosum. Decreased eNOS in diabetic rats was ameliorated by hydrogen-rich saline. therapy may decrease apoptosis in cavernous tissues and it ameliorated erectile dysfunction in diabetic rats by inhibiting oxidative stress and apoptosis.
H₂ Mechanisms / Biological Findings
Hydrogen-rich saline therapy may decrease apoptosis in cavernous tissues and it ameliorated erectile dysfunction in diabetic rats by inhibiting oxidative stress and apoptosis.
Authors’ Conclusion
The authors concluded that hydrogen-rich saline effectively improved erectile function in a streptozotocin induced diabetic rat model of erectile dysfunction.