Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig.
Lihua Wei, Li Ge, Shucun Qin, Yunzhi Shi, Changqing Du, Hui Du, Liwei Liu, Yang Yu, Xuejun Sun · Experimental eye research · 2012
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Independent study record
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H2HUBB TAKEAWAY
In guinea pigs, compared with the glutamate-induced injury group, the hydrogen-rich saline treatment reduced the loss of cells in the GCL and thinning of the retina and attenuated cellular morphological damage. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined guinea pigs.
How Molecular Hydrogen Was Used
After 30 min, hydrogen-rich saline was injected into the vitreous cavity, the peritoneal cavity or both. , the administration of hydrogen-rich saline through the intravitreal or/and intraperitoneal routes could reduce the retinal excitotoxic injury and promote retinal recovery.
What the Researchers Found
Compared with the glutamate-induced injury group, the hydrogen-rich saline treatment reduced the loss of cells in the GCL and thinning of the retina and attenuated cellular morphological damage. The hydrogen-rich saline increased the expression of EAAT-1.
H₂ Mechanisms / Biological Findings
Molecular hydrogen (H(2)) is an efficient antioxidant that can selectively reduce hydroxyl radicals and inhibit oxidative stress-induced injuries. The researchers investigated the protective effects and mechanism of hydrogen-rich saline in a glutamate-induced retinal injury model.
Authors’ Conclusion
The authors concluded that , the administration of hydrogen-rich saline through the intravitreal or/and intraperitoneal routes could reduce the retinal excitotoxic injury and promote retinal recovery.