Hydrogen-rich saline treatment modulates proteomic profiles to mitigate cataract development in a N-methyl-N-nitrosourea-induced rat model.
Yingxin Qu, Xiaoqi Li, Qinghua Yang, Runpu Li, Ye Tao, Yifei Huang, Liqiang Wang · International ophthalmology · 2026
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Independent study record
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H2HUBB TAKEAWAY
In this animal study, the authors report that HRS mitigates MNU-induced cataracts possibly by reducing oxidative stress and downregulating stress-response and metabolic proteins.
What the Researchers Studied
Source-reported study description: Sprague-Dawley rats were assigned to control, MNU-only, MNU + normal saline (NS), MNU + pirenoxine(PRX), and MNU + HRS groups.
Source-reported study description: Cataracts were induced with MNU (postnatal day 15), and treatments (postnatal days 8-21) included intraperitoneal injections and eye drops.
What the Study Found
The authors reported: HRS reduced MNU-induced cataract incidence to 50% versus 100% in MNU-only and NS groups and preserved lens clarity comparable to normal controls.
The authors reported: Domain enrichment showed links to ATPase activity and energy metabolism.
What the Findings Mean
The authors concluded/reported: HRS mitigates MNU-induced cataracts possibly by reducing oxidative stress and downregulating stress-response and metabolic proteins.
Study Details
Publication type: animal_study
Evidence source level: A_FULL_TEXT
Original scholarly source: https://pmc.ncbi.nlm.nih.gov/articles/PMC12819484/