Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway.
Yi Lu, Chun-Fang Li, Na-Na Ping, Yu-Yao Sun, Zheng Wang, Gong-Xiao Zhao, Shi-Hui Yuan, Abdoulaye Issotina Zibrila, Lynn Soong, Jin-Jun Liu · Journal of biochemical and molecular toxicology · 2020
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Independent study record
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H2HUBB TAKEAWAY
In rats,, HRW restored the balance of redox status, suppressed oxidative stress damage, and improved kidney function induced by CsA via activation of the Keap1/Nrf2 signaling pathway. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined rats.
How Molecular Hydrogen Was Used
Although hydrogen-rich water (HRW) has been used to prevent various oxidative stress-related diseases, its underlying mechanisms remain unclear. HRW significantly decreased the level of Keap1 and increased the expression of Nrf2, NADPH dehydrogenase quinone 1, and heme oxygenase 1.
What the Researchers Found
Conversely, HRW decreased levels of ROS and MDA while increasing the activity of GSH and SOD. HRW significantly decreased the level of Keap1 and increased the expression of Nrf2, NADPH dehydrogenase quinone 1, and heme oxygenase 1., HRW restored the balance of redox status, suppressed oxidative stress damage, and improved kidney function induced by CsA via activation of the Keap1/Nrf2 signaling pathway.
H₂ Mechanisms / Biological Findings
Although hydrogen-rich water (HRW) has been used to prevent various oxidative stress-related diseases, its underlying mechanisms remain unclear.
Authors’ Conclusion
The authors concluded that , HRW restored the balance of redox status, suppressed oxidative stress damage, and improved kidney function induced by CsA via activation of the Keap1/Nrf2 signaling pathway.